The Impact of Isolated Increased Nuchal Translucency ≥95th Centile on Perinatal Outcome: A Prospective Cohort Study from a North Indian Genetic Center

Abstract Objectives The aim of this study was to determine the chromosomal abnormalities and other adverse outcomes like miscarriages, intrauterine deaths, structural defects, genetic syndromes in fetuses with increased nuchal translucency (NT) more than or equal 95th centile. This also compared NT between 99th centile Study Design A prospective cohort 182 patients isolated evaluated by invasive testing. Fetal chromosomes were examined fluorescent situ hybridization karyotype microarray. Euploid pregnancies followed-up level II ultrasound fetal echocardiography. For progressing delivery, neonates till age 3 months. Final outcome reported as normal abnormal. Collated data for perinatal analyzed (group I) II). Results Of 202 recruited, consented testing analysis. patients, group I (NT 95–99th centile) included 92 90 patients. Chromosomal present 50 (27.4%), 14 (7.6%) I, 36 (19.4%) II. 132 euploid pregnancies, 22 (16%) fetuses, 7 (5.3%) 15(11.7%) 110 (60.4%) Normal observed 77.1% II, it 43.4%. Conclusion An is associated poor 39.6% analysis follow-up important enable a take home neonatal rate 60.4%. No pregnancy should be discontinued without detailed evaluation disorders, malformation, growth.